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Assay Detail

CHEMBL2174202

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human 293T cells after 24 to 72 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HEK-293T
Confidence 1 — Organism
Curated By Autocuration

Target

HEK-293T (CHEMBL3706568)
Type CELL-LINE
Organism Homo sapiens

Publication

Structure-activity relationship in the antitumor activity of 6-, 8- or 6,8-substituted 3-benzylamino-β-carboline derivatives.
Ikeda R, Kimura T, Tsutsumi T, Tamura S, Sakai N, Konakahara T.
Bioorg Med Chem Lett (2012) 22 : 3506 -3515
PubMed 22520257 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 5.61 6.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2171568 1 6.46
CHEMBL2171569 1 6.44
CHEMBL2171558 1 6.30
CHEMBL2171536 1 6.16
CHEMBL2171540 1 6.00
CHEMBL2171539 1 5.96
CHEMBL2171541 1 5.85
CHEMBL2171559 1 5.85
CHEMBL2171570 1 5.70
CHEMBL2171537 1 5.68
CHEMBL2171556 1 5.64
CHEMBL2171542 1 5.51
CHEMBL2171538 1 5.42
CHEMBL2171543 1 5.40
CHEMBL2171561 1 5.40
CHEMBL2171560 1 5.32
CHEMBL2171555 1 5.24
CHEMBL2171563 1 5.10
CHEMBL2171557 1 5.10
CHEMBL2171567 1 5.01
CHEMBL2171562 1 5.00
CHEMBL2171554 1 4.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2171568 IC50 = 350.0 nM 6.46
CHEMBL2171569 IC50 = 360.0 nM 6.44
CHEMBL2171558 IC50 = 500.0 nM 6.30
CHEMBL2171536 IC50 = 700.0 nM 6.16
CHEMBL2171540 IC50 = 1000.0 nM 6.00
CHEMBL2171539 IC50 = 1100.0 nM 5.96
CHEMBL2171541 IC50 = 1400.0 nM 5.85
CHEMBL2171559 IC50 = 1400.0 nM 5.85
CHEMBL2171570 IC50 = 2000.0 nM 5.70
CHEMBL2171537 IC50 = 2100.0 nM 5.68
CHEMBL2171556 IC50 = 2300.0 nM 5.64
CHEMBL2171542 IC50 = 3100.0 nM 5.51
CHEMBL2171538 IC50 = 3800.0 nM 5.42
CHEMBL2171543 IC50 = 4000.0 nM 5.40
CHEMBL2171561 IC50 = 4000.0 nM 5.40
CHEMBL2171560 IC50 = 4800.0 nM 5.32
CHEMBL2171555 IC50 = 5800.0 nM 5.24
CHEMBL2171563 IC50 = 8000.0 nM 5.10
CHEMBL2171557 IC50 = 8000.0 nM 5.10
CHEMBL2171567 IC50 = 9800.0 nM 5.01
CHEMBL2171562 IC50 = 10000.0 nM 5.00
CHEMBL2171554 IC50 = 15000.0 nM 4.82