Assay Detail

CHEMBL2174330

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Binding

Inhibition of recombinant Aurora A by radioactive flash plate assay

ChEMBL ↗

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Target

Aurora kinase A (CHEMBL4722) ↗

Open DB target context

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Aurora kinase A (CHEMBL4722) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Aurora kinase A

CHEMBL4722

Anchored from Assay target.

Protein identity Aurora kinase A

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Aurora kinase A (CHEMBL4722) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors.

Lawrence HR, Martin MP, Luo Y, Pireddu R, Yang H, Gevariya H, Ozcan S, Zhu JY, Kendig R, Rodriguez M, Elias R, Cheng JQ, Sebti SM, Schonbrunn E, Lawrence NJ.
J Med Chem (2012) 55 : 7392 -7416
PubMed 22803810 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.92	8.92

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL483158	ALISERTIB	3.0	1	8.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL483158	ALISERTIB	IC50	=	1.2	nM	8.92