Assay Detail
Functional
CHEMBL2174685
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of osteoclastogenesis in human bone marrow-derived stem cells assessed as reduction of pit formation by measuring TRACP5b activity after 7 days by bone TRAP assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.28 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371064 | BALICATIB | 2.0 | 1 | 7.58 |
| CHEMBL2163587 | — | — | 1 | 7.50 |
| CHEMBL2172005 | — | — | 1 | 7.40 |
| CHEMBL481611 | ODANACATIB | 3.0 | 1 | 7.00 |
| CHEMBL2171993 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371064 | BALICATIB | IC50 | = | 26.6 | nM | 7.58 |
| CHEMBL2163587 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2172005 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL481611 | ODANACATIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2171993 | — | IC50 | = | 126.0 | nM | 6.90 |