Assay Detail
Binding
CHEMBL2174777
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cloned human recombinant PDE7B assessed as [3H]cAMP hydrolysis by radiometric assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 7B (CHEMBL4716) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson's disease model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.68 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2171422 | — | — | 1 | 7.96 |
| CHEMBL2171423 | — | — | 1 | 7.72 |
| CHEMBL2171421 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2171422 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2171423 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2171421 | — | IC50 | = | 43.0 | nM | 7.37 |