Assay Detail
Binding
CHEMBL2174779
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cloned human recombinant PDE7A assessed as [3H]cAMP hydrolysis by radiometric assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (CHEMBL3012) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson's disease model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.37 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2171440 | — | — | 1 | 8.52 |
| CHEMBL2171423 | — | — | 1 | 7.92 |
| CHEMBL2171435 | — | — | 1 | 7.75 |
| CHEMBL2171436 | — | — | 1 | 7.62 |
| CHEMBL2171422 | — | — | 1 | 7.57 |
| CHEMBL2171421 | — | — | 1 | 7.51 |
| CHEMBL2171434 | — | — | 1 | 7.50 |
| CHEMBL2171433 | — | — | 1 | 7.48 |
| CHEMBL2171429 | — | — | 1 | 7.35 |
| CHEMBL2171430 | — | — | 1 | 7.28 |
| CHEMBL2171428 | — | — | 1 | 7.26 |
| CHEMBL2171437 | — | — | 1 | 7.17 |
| CHEMBL2171431 | — | — | 1 | 7.15 |
| CHEMBL2171427 | — | — | 1 | 7.14 |
| CHEMBL2171442 | — | — | 1 | 7.12 |
| CHEMBL2171426 | — | — | 1 | 7.11 |
| CHEMBL2171425 | — | — | 1 | 7.10 |
| CHEMBL2171432 | — | — | 1 | 7.09 |
| CHEMBL2171438 | — | — | 1 | 7.05 |
| CHEMBL2171439 | — | — | 1 | 7.03 |
| CHEMBL2171424 | — | — | 1 | 6.98 |
| CHEMBL2171441 | — | — | 1 | - |
| CHEMBL2171443 | — | — | 1 | - |
| CHEMBL2171444 | — | — | 1 | - |
| CHEMBL2171445 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2171440 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2171423 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2171435 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2171436 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2171422 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2171421 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2171434 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2171433 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2171429 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2171430 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL2171428 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL2171437 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL2171431 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL2171427 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL2171442 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2171426 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL2171425 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2171432 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL2171438 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL2171439 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL2171424 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL2171441 | — | IC50 | - | — | - | |
| CHEMBL2171443 | — | IC50 | - | — | - | |
| CHEMBL2171444 | — | IC50 | - | — | - | |
| CHEMBL2171445 | — | IC50 | - | — | - |