Assay Detail
Functional
CHEMBL2175069
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Cytotoxicity against human PC3 cells measured on day 7 by MTT assay
21
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of pH-dependent hydrolyzable emetine analogues as treatment for prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.68 | 7.53 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL493439 | EMETINE HYDROCHLORIDE | 2.0 | 2 | 7.53 |
| CHEMBL2171637 | — | — | 1 | 7.06 |
| CHEMBL2171642 | — | — | 1 | 6.42 |
| CHEMBL2171645 | — | — | 1 | 6.37 |
| CHEMBL2171638 | — | — | 1 | 5.81 |
| CHEMBL2171640 | — | — | 1 | 5.68 |
| CHEMBL2171643 | — | — | 1 | 5.67 |
| CHEMBL2171646 | — | — | 1 | 5.54 |
| CHEMBL2171649 | — | — | 1 | 5.54 |
| CHEMBL2171753 | — | — | 1 | 5.43 |
| CHEMBL2171635 | — | — | 1 | 5.38 |
| CHEMBL2171641 | — | — | 1 | 5.30 |
| CHEMBL2171648 | — | — | 1 | 5.30 |
| CHEMBL2171639 | — | — | 1 | 5.22 |
| CHEMBL2171636 | — | — | 1 | 5.22 |
| CHEMBL2171647 | — | — | 1 | 5.16 |
| CHEMBL2171752 | — | — | 1 | 5.12 |
| CHEMBL2171644 | — | — | 1 | 5.11 |
| CHEMBL2171754 | — | — | 1 | 5.00 |
| CHEMBL2171755 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL493439 | EMETINE HYDROCHLORIDE | IC50 | = | 29.43 | nM | 7.53 |
| CHEMBL2171637 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL2171642 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL2171645 | — | IC50 | = | 428.0 | nM | 6.37 |
| CHEMBL2171638 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL2171640 | — | IC50 | = | 2102.0 | nM | 5.68 |
| CHEMBL2171643 | — | IC50 | = | 2149.0 | nM | 5.67 |
| CHEMBL2171646 | — | IC50 | = | 2889.0 | nM | 5.54 |
| CHEMBL2171649 | — | IC50 | = | 2864.0 | nM | 5.54 |
| CHEMBL2171753 | — | IC50 | = | 3669.0 | nM | 5.43 |
| CHEMBL2171635 | — | IC50 | = | 4214.0 | nM | 5.38 |
| CHEMBL2171641 | — | IC50 | = | 5041.0 | nM | 5.30 |
| CHEMBL2171648 | — | IC50 | = | 5002.0 | nM | 5.30 |
| CHEMBL2171636 | — | IC50 | = | 6075.0 | nM | 5.22 |
| CHEMBL2171639 | — | IC50 | = | 6071.0 | nM | 5.22 |
| CHEMBL2171647 | — | IC50 | = | 6916.0 | nM | 5.16 |
| CHEMBL2171752 | — | IC50 | = | 7613.0 | nM | 5.12 |
| CHEMBL2171644 | — | IC50 | = | 7708.0 | nM | 5.11 |
| CHEMBL2171754 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2171755 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL493439 | EMETINE HYDROCHLORIDE | Activity | - | — | - |