Assay Detail
Functional
CHEMBL2175131
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Inhibition of ADP-stimulated platelet aggregation in human isolated platelets by light transmission aggregometry based Born method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Platelet |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of high-affinity P2Y₁₂ antagonists based on a phenylpyrazole glutamic acid piperazine backbone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.24 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2172272 | — | — | 1 | 8.15 |
| CHEMBL2172140 | — | — | 1 | 7.66 |
| CHEMBL2172139 | — | — | 1 | 7.00 |
| CHEMBL2172277 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2172272 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2172140 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2172139 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL2172277 | — | IC50 | = | 701.0 | nM | 6.15 |