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Assay Detail

CHEMBL2175135

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of ADP-stimulated platelet aggregation in human platelet rich plasma by 96-well format based turbidimetric method
63
Total Activities
63
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Tissue Plasma
Cell Type Platelet
Confidence 1 — Organism
Curated By Autocuration

Target

Platelet (CHEMBL4296519)
Type CELL-LINE

Publication

Identification of high-affinity P2Y₁₂ antagonists based on a phenylpyrazole glutamic acid piperazine backbone.
Zech G, Hessler G, Evers A, Weiss T, Florian P, Just M, Czech J, Czechtizky W, Görlitzer J, Ruf S, Kohlmann M, Nazaré M.
J Med Chem (2012) 55 : 8615 -8629
PubMed 22984835 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 63 6.39 7.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2172273 1 7.89
CHEMBL2172270 1 7.89
CHEMBL2172150 1 7.85
CHEMBL2172269 1 7.77
CHEMBL2172149 1 7.72
CHEMBL2172148 1 7.68
CHEMBL2172272 1 7.60
CHEMBL2172140 1 7.52
CHEMBL2172268 1 7.40
CHEMBL2172128 1 7.40
CHEMBL2172129 1 7.30
CHEMBL2172267 1 7.24
CHEMBL2172161 1 7.16
CHEMBL2172151 1 7.14
CHEMBL2172157 1 7.12
CHEMBL2172139 1 7.05
CHEMBL2172133 1 7.04
CHEMBL2172156 1 7.00
CHEMBL2172146 1 6.91
CHEMBL2172127 1 6.89
CHEMBL2172132 1 6.68
CHEMBL2172274 1 6.66
CHEMBL2172163 1 6.54
CHEMBL2172154 1 6.47
CHEMBL2172162 1 6.42
CHEMBL2172152 1 6.37
CHEMBL2172266 1 6.32
CHEMBL2172165 1 6.26
CHEMBL2172160 1 6.22
CHEMBL2172131 1 6.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2172273 IC50 = 13.0 nM 7.89
CHEMBL2172270 IC50 = 13.0 nM 7.89
CHEMBL2172150 IC50 = 14.0 nM 7.85
CHEMBL2172269 IC50 = 17.0 nM 7.77
CHEMBL2172149 IC50 = 19.0 nM 7.72
CHEMBL2172148 IC50 = 21.0 nM 7.68
CHEMBL2172272 IC50 = 25.0 nM 7.60
CHEMBL2172140 IC50 = 30.0 nM 7.52
CHEMBL2172268 IC50 = 40.0 nM 7.40
CHEMBL2172128 IC50 = 40.0 nM 7.40
CHEMBL2172129 IC50 = 50.0 nM 7.30
CHEMBL2172267 IC50 = 58.0 nM 7.24
CHEMBL2172161 IC50 = 70.0 nM 7.16
CHEMBL2172151 IC50 = 72.0 nM 7.14
CHEMBL2172157 IC50 = 76.0 nM 7.12
CHEMBL2172139 IC50 = 90.0 nM 7.05
CHEMBL2172133 IC50 = 92.0 nM 7.04
CHEMBL2172156 IC50 = 100.0 nM 7.00
CHEMBL2172146 IC50 = 124.0 nM 6.91
CHEMBL2172127 IC50 = 130.0 nM 6.89
CHEMBL2172132 IC50 = 210.0 nM 6.68
CHEMBL2172274 IC50 = 220.0 nM 6.66
CHEMBL2172163 IC50 = 290.0 nM 6.54
CHEMBL2172154 IC50 = 335.0 nM 6.47
CHEMBL2172162 IC50 = 380.0 nM 6.42
CHEMBL2172152 IC50 = 430.0 nM 6.37
CHEMBL2172266 IC50 = 475.0 nM 6.32
CHEMBL2172165 IC50 = 555.0 nM 6.26
CHEMBL2172160 IC50 = 600.0 nM 6.22
CHEMBL2172131 IC50 = 675.0 nM 6.17
CHEMBL2172143 IC50 = 790.0 nM 6.10
CHEMBL2172166 IC50 = 900.0 nM 6.05
CHEMBL2172147 IC50 = 1080.0 nM 5.97
CHEMBL2172155 IC50 = 1200.0 nM 5.92
CHEMBL2172145 IC50 = 1230.0 nM 5.91
CHEMBL2172144 IC50 = 1330.0 nM 5.88
CHEMBL2172284 IC50 = 1370.0 nM 5.86
CHEMBL2172265 IC50 = 1460.0 nM 5.84
CHEMBL2172153 IC50 = 1510.0 nM 5.82
CHEMBL398435 TICAGRELOR IC50 = 1830.0 nM 5.74
CHEMBL2172141 IC50 = 1880.0 nM 5.73
CHEMBL2172137 IC50 = 1900.0 nM 5.72
CHEMBL2172138 IC50 = 2210.0 nM 5.66
CHEMBL2172278 IC50 = 2250.0 nM 5.65
CHEMBL2172134 IC50 = 2400.0 nM 5.62
CHEMBL2172275 IC50 = 2600.0 nM 5.58
CHEMBL2172280 IC50 = 2600.0 nM 5.58
CHEMBL2103828 ELINOGREL IC50 = 2810.0 nM 5.55
CHEMBL2172159 IC50 = 2940.0 nM 5.53
CHEMBL2172264 IC50 = 3100.0 nM 5.51