Assay Detail
Binding
CHEMBL2175143
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Displacement of [3H]-(+)-MK-801 from PCP binding site of NMDA receptor in pig brain cortex
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Enantiomerically pure 1,3-dioxanes as highly selective NMDA and σ₁ receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.88 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344151 | DIZOCILPINE MALEATE | -1.0 | 1 | 8.52 |
| CHEMBL1783455 | — | — | 1 | 7.89 |
| CHEMBL2170309 | — | — | 1 | 7.68 |
| CHEMBL2170304 | — | — | 1 | 7.64 |
| CHEMBL1165411 | DEXOXADROL | 2.0 | 1 | 7.50 |
| CHEMBL2170306 | — | — | 1 | 7.34 |
| CHEMBL275528 | PHENCYCLIDINE | 2.0 | 1 | 7.23 |
| CHEMBL2170311 | — | — | 1 | 6.52 |
| CHEMBL395091 | ESKETAMINE | 4.0 | 1 | 6.42 |
| CHEMBL2170310 | — | — | 1 | 6.40 |
| CHEMBL807 | MEMANTINE | 4.0 | 1 | 6.37 |
| CHEMBL2170307 | — | — | 1 | 5.83 |
| CHEMBL2170308 | — | — | 1 | 5.82 |
| CHEMBL2170305 | — | — | 1 | 5.21 |
| CHEMBL2170315 | — | — | 1 | - |
| CHEMBL1783426 | — | — | 1 | - |
| CHEMBL2170312 | — | — | 1 | - |
| CHEMBL1783450 | — | — | 1 | - |
| CHEMBL2170313 | — | — | 1 | - |
| CHEMBL2170314 | — | — | 1 | - |
| CHEMBL2170178 | — | — | 1 | - |
| CHEMBL1783458 | — | — | 1 | - |
| CHEMBL2170179 | — | — | 1 | - |
| CHEMBL2170180 | — | — | 1 | - |
| CHEMBL2170301 | — | — | 1 | - |
| CHEMBL2170302 | — | — | 1 | - |
| CHEMBL2170303 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344151 | DIZOCILPINE MALEATE | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1783455 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL2170309 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL2170304 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL1165411 | DEXOXADROL | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL2170306 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL275528 | PHENCYCLIDINE | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL2170311 | — | Ki | = | 304.0 | nM | 6.52 |
| CHEMBL395091 | ESKETAMINE | Ki | = | 383.0 | nM | 6.42 |
| CHEMBL2170310 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL807 | MEMANTINE | Ki | = | 429.0 | nM | 6.37 |
| CHEMBL2170307 | — | Ki | = | 1490.0 | nM | 5.83 |
| CHEMBL2170308 | — | Ki | = | 1530.0 | nM | 5.82 |
| CHEMBL2170305 | — | Ki | = | 6120.0 | nM | 5.21 |
| CHEMBL2170315 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783426 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2170312 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783450 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2170313 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2170314 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2170178 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1783458 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2170179 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2170180 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2170301 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2170302 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2170303 | — | Ki | > | 10000.0 | nM | - |