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Assay Detail

CHEMBL2175146

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antischistosomal activity against adult Schistosoma mansoni schistosomes incubated for 72 hrs in presence of 120 uM Fe(3)-hemin
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Schistosoma mansoni
Confidence 1 — Organism
Curated By Autocuration

Target

Schistosoma mansoni (CHEMBL612893)
Type ORGANISM
Organism Schistosoma mansoni

Publication

Identification of antischistosomal leads by evaluating bridged 1,2,4,5-tetraoxanes, alphaperoxides, and tricyclic monoperoxides.
Ingram K, Yaremenko IA, Krylov IB, Hofer L, Terent'ev AO, Keiser J.
J Med Chem (2012) 55 : 8700 -8711
PubMed 23013253 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.48 4.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2170514 1 4.89
CHEMBL2170333 1 4.87
CHEMBL2170361 1 4.75
CHEMBL2170509 1 4.60
CHEMBL2170508 1 4.56
CHEMBL2170512 1 4.41
CHEMBL361497 ARTESUNATE 4.0 1 4.41
CHEMBL2170511 1 4.38
CHEMBL2170513 1 4.32
CHEMBL2169887 1 4.04
CHEMBL2170332 1 4.04
CHEMBL2169892 1 -
CHEMBL2170317 1 -
CHEMBL2170316 1 -
CHEMBL2170516 1 -
CHEMBL2170515 1 -
CHEMBL2170510 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2170514 IC50 = 12900.0 nM 4.89
CHEMBL2170333 IC50 = 13400.0 nM 4.87
CHEMBL2170361 IC50 = 17900.0 nM 4.75
CHEMBL2170509 IC50 = 25300.0 nM 4.60
CHEMBL2170508 IC50 = 27300.0 nM 4.56
CHEMBL2170512 IC50 = 39300.0 nM 4.41
CHEMBL361497 ARTESUNATE IC50 = 38700.0 nM 4.41
CHEMBL2170511 IC50 = 41200.0 nM 4.38
CHEMBL2170513 IC50 = 47700.0 nM 4.32
CHEMBL2169887 IC50 = 91900.0 nM 4.04
CHEMBL2170332 IC50 = 92200.0 nM 4.04
CHEMBL2169892 IC50 = 134900.0 nM -
CHEMBL2170317 IC50 > 112000.0 nM -
CHEMBL2170316 IC50 > 89800.0 nM -
CHEMBL2170516 IC50 > 174000.0 nM -
CHEMBL2170515 IC50 > 127000.0 nM -
CHEMBL2170510 IC50 > 159000.0 nM -