Assay Detail
Binding
CHEMBL2175187
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of STAT3 dimerization in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction in nucleus after 30 mins by EMSA
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 3 (CHEMBL5402) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.35 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2171897 | — | — | 1 | 4.60 |
| CHEMBL2172017 | — | — | 1 | 4.55 |
| CHEMBL2172015 | — | — | 1 | 4.48 |
| CHEMBL1829786 | — | — | 1 | 4.46 |
| CHEMBL392556 | — | — | 1 | 4.38 |
| CHEMBL2023986 | — | — | 1 | 4.37 |
| CHEMBL2172013 | — | — | 1 | 4.37 |
| CHEMBL2172014 | — | — | 1 | 4.35 |
| CHEMBL2023987 | — | — | 1 | 4.30 |
| CHEMBL2172018 | — | — | 1 | 4.24 |
| CHEMBL477936 | — | — | 1 | 4.07 |
| CHEMBL2172016 | — | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2171897 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL2172017 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL2172015 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL1829786 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL392556 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL2023986 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL2172013 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL2172014 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL2023987 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL2172018 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL477936 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL2172016 | — | IC50 | = | 90000.0 | nM | 4.05 |