Assay Detail
Binding
CHEMBL2175252
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Displacement of [3H]-AVP from human vasopressin V1a receptor expressed in CHO cells after 30 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective fluorescent nonpeptidic antagonists for vasopressin V₂ GPCR: application to ligand screening and oligomerization assays.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.42 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373742 | VASOPRESSIN | 4.0 | 1 | 9.15 |
| CHEMBL603708 | — | — | 1 | 8.56 |
| CHEMBL2172289 | — | — | 1 | 6.21 |
| CHEMBL2172290 | — | — | 1 | 5.76 |
| CHEMBL2172288 | — | — | 1 | - |
| CHEMBL2172295 | — | — | 1 | - |
| CHEMBL2172294 | — | — | 1 | - |
| CHEMBL2172293 | — | — | 1 | - |
| CHEMBL2172292 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373742 | VASOPRESSIN | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL603708 | — | Ki | = | 2.74 | nM | 8.56 |
| CHEMBL2172289 | — | Ki | = | 621.0 | nM | 6.21 |
| CHEMBL2172290 | — | Ki | = | 1753.0 | nM | 5.76 |
| CHEMBL2172288 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2172295 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2172294 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2172293 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2172292 | — | Ki | > | 10000.0 | nM | - |