Assay Detail
Binding
CHEMBL2175301
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tetrahymena telomerase using 3'-ACT TCG TAG AGC AGA TTG-5' as substrate incubated for 10 mins prior to extension reaction by telomeric repeat amplification protocol
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Tetrahymena |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A new strategy for detection and development of tractable telomerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.40 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2170855 | — | — | 1 | 6.85 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 6.43 |
| CHEMBL222541 | — | — | 1 | 6.21 |
| CHEMBL2170857 | — | — | 1 | 6.09 |
| CHEMBL2170856 | — | — | 1 | - |
| CHEMBL27323 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2170855 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL222541 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL2170857 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL2170856 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL27323 | — | IC50 | > | 200000.0 | nM | - |