Assay Detail
Binding
CHEMBL2175309
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction by telomeric repeat amplification protocol
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A new strategy for detection and development of tractable telomerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.01 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2170855 | — | — | 1 | 7.22 |
| CHEMBL222541 | — | — | 1 | 6.64 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 5.93 |
| CHEMBL2170857 | — | — | 1 | 5.88 |
| CHEMBL27323 | — | — | 1 | 5.44 |
| CHEMBL2170856 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2170855 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL222541 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL2170857 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL27323 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2170856 | — | IC50 | = | 12100.0 | nM | 4.92 |