Assay Detail
Binding
CHEMBL2175310
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction followed by compound washout by spin-telomeric repeat amplification protocol
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A new strategy for detection and development of tractable telomerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.91 | 6.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2170855 | — | — | 1 | 6.83 |
| CHEMBL222541 | — | — | 1 | 6.60 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 5.97 |
| CHEMBL2170857 | — | — | 1 | 5.82 |
| CHEMBL27323 | — | — | 1 | 5.34 |
| CHEMBL2170856 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2170855 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL222541 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL2170857 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL27323 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL2170856 | — | IC50 | = | 12800.0 | nM | 4.89 |