Assay Detail
Binding
CHEMBL2175401
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Inhibition of human rhinovirus 14 recombinant N-terminal GST-tagged protease 3c expressed in Escherichia coli DH5alpha using LEVLFQGPSK(Fluoro)G as substrate after 1 hr by discontinuous heterogeneous fluorometric assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | rhinovirus B14 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A simple solid phase, peptide-based fluorescent assay for the efficient and universal screening of HRV 3C protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.59 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL349148 | 2-Bromo-1,4-naphthoquinone | — | 1 | 5.38 |
| CHEMBL2172471 | — | — | 1 | 5.06 |
| CHEMBL596082 | — | — | 1 | 4.28 |
| CHEMBL2172472 | — | — | 1 | 4.20 |
| CHEMBL2172473 | — | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL349148 | 2-Bromo-1,4-naphthoquinone | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL2172471 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL596082 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL2172472 | — | IC50 | = | 62700.0 | nM | 4.20 |
| CHEMBL2172473 | — | IC50 | = | 92500.0 | nM | 4.03 |