Assay Detail
Binding
CHEMBL2175528
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNFalpha-induced human NFkappaB activity in HEK293 cells incubated for 6 hrs followed by compound wash out measured after 5 mins by by luciferase assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.21 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2172205 | — | — | 1 | 6.40 |
| CHEMBL2172211 | — | — | 1 | 6.22 |
| CHEMBL2172207 | — | — | 1 | 6.16 |
| CHEMBL403183 | — | — | 1 | 5.70 |
| CHEMBL242413 | — | — | 1 | 5.58 |
| CHEMBL2172209 | — | — | 1 | 5.43 |
| CHEMBL60718 | TPCK | — | 1 | 5.29 |
| CHEMBL2172300 | — | — | 1 | 5.14 |
| CHEMBL2172299 | — | — | 1 | 4.84 |
| CHEMBL2172212 | — | — | 1 | 4.58 |
| CHEMBL2172206 | — | — | 1 | 4.49 |
| CHEMBL2172298 | — | — | 1 | 4.41 |
| CHEMBL2172210 | — | — | 1 | 4.40 |
| CHEMBL2172217 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2172205 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2172211 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2172207 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL403183 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL242413 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2172209 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL60718 | TPCK | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL2172300 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2172299 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL2172212 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL2172206 | — | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL2172298 | — | IC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL2172210 | — | IC50 | = | 39800.0 | nM | 4.40 |
| CHEMBL2172217 | — | IC50 | = | 49300.0 | nM | 4.31 |