Assay Detail
Functional
CHEMBL2175533
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human RXRalpha expressed in african green monkey COS1 cells assessed as induction of RXRE transcriptional activity after 12 hrs by luciferase reporter gene assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COS-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.07 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2172212 | — | — | 1 | 5.47 |
| CHEMBL2172208 | — | — | 1 | 5.12 |
| CHEMBL2172210 | — | — | 1 | 5.00 |
| CHEMBL2172299 | — | — | 1 | 4.68 |
| CHEMBL2172214 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2172212 | — | EC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL2172208 | — | EC50 | = | 7650.0 | nM | 5.12 |
| CHEMBL2172210 | — | EC50 | = | 9960.0 | nM | 5.00 |
| CHEMBL2172299 | — | EC50 | = | 20910.0 | nM | 4.68 |
| CHEMBL2172214 | — | EC50 | > | 41400.0 | nM | - |