Assay Detail
Binding
CHEMBL2175548
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Inhibition of mTORC1-mediated pS6 Ser240/244-phosphorylation in human U87MG cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.97 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2172637 | — | — | 1 | 7.16 |
| CHEMBL1615183 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2172637 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL1615183 | — | IC50 | = | 166.0 | nM | 6.78 |