Assay Detail
Binding
CHEMBL2175578
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Inhibition of human recombinant AKR1C1 assessed as 1-acenaphthenol oxidation by spectrophotometry
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member C1 (CHEMBL5905) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment library.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 4.42 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL686 | MEFENAMIC ACID | 4.0 | 1 | 6.09 |
| CHEMBL2172254 | — | — | 1 | 5.40 |
| CHEMBL1527416 | — | — | 1 | 4.72 |
| CHEMBL2172252 | — | — | 1 | 4.57 |
| CHEMBL2172243 | — | — | 1 | 4.51 |
| CHEMBL1373742 | — | — | 1 | 4.30 |
| CHEMBL2172255 | — | — | 1 | 4.25 |
| CHEMBL2172256 | — | — | 1 | 4.19 |
| CHEMBL1414132 | — | — | 1 | 4.18 |
| CHEMBL2172257 | — | — | 1 | 4.16 |
| CHEMBL1580175 | — | — | 1 | 4.05 |
| CHEMBL2172251 | — | — | 1 | 4.05 |
| CHEMBL1328030 | — | — | 1 | 3.99 |
| CHEMBL1896308 | — | — | 1 | 3.91 |
| CHEMBL2172241 | — | — | 1 | 3.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL686 | MEFENAMIC ACID | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL2172254 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL1527416 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL2172252 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL2172243 | — | Ki | = | 31000.0 | nM | 4.51 |
| CHEMBL1373742 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL2172255 | — | Ki | = | 56000.0 | nM | 4.25 |
| CHEMBL2172256 | — | Ki | = | 64000.0 | nM | 4.19 |
| CHEMBL1414132 | — | Ki | = | 66000.0 | nM | 4.18 |
| CHEMBL2172257 | — | Ki | = | 69000.0 | nM | 4.16 |
| CHEMBL1580175 | — | Ki | = | 89000.0 | nM | 4.05 |
| CHEMBL2172251 | — | Ki | = | 90000.0 | nM | 4.05 |
| CHEMBL1328030 | — | Ki | = | 103000.0 | nM | 3.99 |
| CHEMBL1896308 | — | Ki | = | 124000.0 | nM | 3.91 |
| CHEMBL2172241 | — | Ki | = | 122000.0 | nM | 3.91 |