Assay Detail
Functional
CHEMBL2175609
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Cytotoxicity against human MV4-11 cells harboring MLL-AF4 oncogene after 20 days by XTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship investigation of adenosine-containing inhibitors of histone methyltransferase DOT1L.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.20 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2171169 | — | — | 1 | 5.36 |
| CHEMBL2171170 | — | — | 1 | 5.25 |
| CHEMBL2171172 | — | — | 1 | 5.23 |
| CHEMBL2171171 | — | — | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2171169 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL2171170 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2171172 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL2171171 | — | EC50 | = | 11200.0 | nM | 4.95 |