Assay Detail
Binding
CHEMBL2175615
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PRMT1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 1 (CHEMBL5524) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationship investigation of adenosine-containing inhibitors of histone methyltransferase DOT1L.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.52 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418052 | S-ADENOSYLHOMOCYSTEINE | — | 1 | 6.40 |
| CHEMBL2171174 | — | — | 1 | 4.64 |
| CHEMBL2171172 | — | — | 1 | - |
| CHEMBL2171171 | — | — | 1 | - |
| CHEMBL2171170 | — | — | 1 | - |
| CHEMBL2171169 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418052 | S-ADENOSYLHOMOCYSTEINE | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL2171174 | — | Ki | = | 22700.0 | nM | 4.64 |
| CHEMBL2171172 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL2171171 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL2171170 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL2171169 | — | Ki | > | 100000.0 | nM | - |