Assay Detail
Binding
CHEMBL2175689
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Inhibition of human recombinant AKR1C1 assessed as 1-acenaphthenol oxidation at 400 uM by spectrophotometry
15
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member C1 (CHEMBL5905) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment library.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 14 | - | - |
| Ki | 1 | 8.39 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL387536 | — | — | 1 | 8.39 |
| CHEMBL366350 | — | — | 1 | - |
| CHEMBL2172259 | — | — | 1 | - |
| CHEMBL2172258 | — | — | 1 | - |
| CHEMBL2172253 | — | — | 1 | - |
| CHEMBL2172250 | — | — | 1 | - |
| CHEMBL2172249 | — | — | 1 | - |
| CHEMBL2172248 | — | — | 1 | - |
| CHEMBL2172247 | — | — | 1 | - |
| CHEMBL2172246 | — | — | 1 | - |
| CHEMBL2172245 | — | — | 1 | - |
| CHEMBL2172244 | — | — | 1 | - |
| CHEMBL2172242 | — | — | 1 | - |
| CHEMBL2172240 | — | — | 1 | - |
| CHEMBL2172239 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL387536 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL366350 | — | Inhibition | = | 43.5 | % | - |
| CHEMBL2172259 | — | Inhibition | < | 10.0 | % | - |
| CHEMBL2172258 | — | Inhibition | < | 10.0 | % | - |
| CHEMBL2172253 | — | Inhibition | < | 10.0 | % | - |
| CHEMBL2172250 | — | Inhibition | = | 43.1 | % | - |
| CHEMBL2172249 | — | Inhibition | = | 44.8 | % | - |
| CHEMBL2172248 | — | Inhibition | = | 39.5 | % | - |
| CHEMBL2172247 | — | Inhibition | < | 10.0 | % | - |
| CHEMBL2172246 | — | Inhibition | = | 47.4 | % | - |
| CHEMBL2172245 | — | Inhibition | < | 10.0 | % | - |
| CHEMBL2172244 | — | Inhibition | = | 22.5 | % | - |
| CHEMBL2172242 | — | Inhibition | < | 10.0 | % | - |
| CHEMBL2172240 | — | Inhibition | < | 10.0 | % | - |
| CHEMBL2172239 | — | Inhibition | = | 30.1 | % | - |