Assay Detail
Functional
CHEMBL2175736
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Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.06 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.89 |
| CHEMBL2172710 | — | — | 1 | 6.28 |
| CHEMBL2172732 | — | — | 1 | 6.27 |
| CHEMBL2172733 | — | — | 1 | 5.99 |
| CHEMBL2172720 | — | — | 1 | 5.93 |
| CHEMBL2172708 | — | — | 1 | 5.90 |
| CHEMBL2172712 | — | — | 1 | 5.89 |
| CHEMBL2172734 | — | — | 1 | 5.84 |
| CHEMBL2172709 | — | — | 1 | 5.80 |
| CHEMBL2172731 | — | — | 1 | 5.76 |
| CHEMBL2172713 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63 | ROLIPRAM | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2172710 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2172732 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2172733 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL2172720 | — | EC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL2172708 | — | EC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL2172712 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2172734 | — | EC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL2172709 | — | EC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL2172731 | — | EC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL2172713 | — | EC50 | - | — | - |