Assay Detail
Binding
CHEMBL2175745
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine PDE3 using [3H]cAMP as substrate
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.04 | 5.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2172708 | — | — | 1 | 5.35 |
| CHEMBL2172709 | — | — | 1 | 5.21 |
| CHEMBL2172734 | — | — | 1 | 5.17 |
| CHEMBL2172733 | — | — | 1 | 5.17 |
| CHEMBL2172710 | — | — | 1 | 4.93 |
| CHEMBL2172720 | — | — | 1 | 4.73 |
| CHEMBL2172731 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2172708 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL2172709 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL2172734 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL2172733 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL2172710 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL2172720 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL2172731 | — | IC50 | = | 19600.0 | nM | 4.71 |