Assay Detail
Binding
CHEMBL2175751
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PDE4D
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.67 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2172710 | — | — | 1 | 7.51 |
| CHEMBL2172734 | — | — | 1 | 7.13 |
| CHEMBL2172731 | — | — | 1 | 6.85 |
| CHEMBL2172707 | — | — | 1 | 6.21 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.21 |
| CHEMBL313842 | ZARDAVERINE | 2.0 | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2172710 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2172734 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL2172731 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2172707 | — | IC50 | = | 622.0 | nM | 6.21 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 622.0 | nM | 6.21 |
| CHEMBL313842 | ZARDAVERINE | IC50 | = | 800.0 | nM | 6.10 |