Assay Detail
Binding
CHEMBL2175863
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Inhibition of bovine PDE4 using [3H]cAMP as substrate
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.41 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2172710 | — | — | 1 | 7.30 |
| CHEMBL2172734 | — | — | 1 | 6.98 |
| CHEMBL2172732 | — | — | 1 | 6.96 |
| CHEMBL2172731 | — | — | 1 | 6.85 |
| CHEMBL2172733 | — | — | 1 | 6.82 |
| CHEMBL2172712 | — | — | 1 | 6.72 |
| CHEMBL2172709 | — | — | 1 | 6.68 |
| CHEMBL2172708 | — | — | 1 | 6.54 |
| CHEMBL2172720 | — | — | 1 | 6.52 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.10 |
| CHEMBL2172713 | — | — | 1 | 5.39 |
| CHEMBL2172714 | — | — | 1 | 5.28 |
| CHEMBL2172715 | — | — | 1 | 5.14 |
| CHEMBL2172727 | — | — | 1 | - |
| CHEMBL2172726 | — | — | 1 | - |
| CHEMBL2172725 | — | — | 1 | - |
| CHEMBL2172724 | — | — | 1 | - |
| CHEMBL2172723 | — | — | 1 | - |
| CHEMBL2172722 | — | — | 1 | - |
| CHEMBL2172730 | — | — | 1 | - |
| CHEMBL2172711 | — | — | 1 | - |
| CHEMBL2172719 | — | — | 1 | - |
| CHEMBL2172718 | — | — | 1 | - |
| CHEMBL2172717 | — | — | 1 | - |
| CHEMBL538930 | — | — | 1 | - |
| CHEMBL2172716 | — | — | 1 | - |
| CHEMBL2172736 | — | — | 1 | - |
| CHEMBL551629 | — | — | 1 | - |
| CHEMBL2172735 | — | — | 1 | - |
| CHEMBL2172721 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2172710 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2172734 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL2172732 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2172731 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2172733 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2172712 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2172709 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2172708 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL2172720 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2172713 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL2172714 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL2172715 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2172729 | — | IC50 | - | — | - | |
| CHEMBL2172728 | — | IC50 | - | — | - | |
| CHEMBL541778 | — | IC50 | - | — | - | |
| CHEMBL2172727 | — | IC50 | - | — | - | |
| CHEMBL2172726 | — | IC50 | - | — | - | |
| CHEMBL2172725 | — | IC50 | - | — | - | |
| CHEMBL2172724 | — | IC50 | - | — | - | |
| CHEMBL2172723 | — | IC50 | - | — | - | |
| CHEMBL2172722 | — | IC50 | - | — | - | |
| CHEMBL2172730 | — | IC50 | - | — | - | |
| CHEMBL2172711 | — | IC50 | - | — | - | |
| CHEMBL2172719 | — | IC50 | - | — | - | |
| CHEMBL2172718 | — | IC50 | - | — | - | |
| CHEMBL2172717 | — | IC50 | - | — | - | |
| CHEMBL538930 | — | IC50 | - | — | - | |
| CHEMBL2172716 | — | IC50 | - | — | - | |
| CHEMBL2172736 | — | IC50 | - | — | - | |
| CHEMBL551629 | — | IC50 | - | — | - | |
| CHEMBL2172735 | — | IC50 | - | — | - | |
| CHEMBL2172721 | — | IC50 | - | — | - |