Assay Detail
Binding
CHEMBL2176058
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
38
Total Activities
38
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Eukaryotic initiation factor 4A-I (CHEMBL2052028) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 37 | 8.23 | 9.70 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2170713 | — | — | 1 | 9.70 |
| CHEMBL2170563 | — | — | 1 | 9.22 |
| CHEMBL555196 | SILVESTROL | — | 1 | 9.10 |
| CHEMBL2170562 | — | — | 1 | 9.10 |
| CHEMBL2170556 | — | — | 1 | 9.05 |
| CHEMBL2170714 | — | — | 1 | 9.00 |
| CHEMBL2170555 | — | — | 1 | 9.00 |
| CHEMBL2170703 | — | — | 1 | 8.92 |
| CHEMBL2170559 | — | — | 1 | 8.70 |
| CHEMBL2170725 | — | — | 1 | 8.52 |
| CHEMBL2170718 | — | — | 1 | 8.52 |
| CHEMBL2170722 | — | — | 1 | 8.52 |
| CHEMBL2170560 | — | — | 1 | 8.52 |
| CHEMBL2170561 | — | — | 1 | 8.52 |
| CHEMBL2170557 | — | — | 1 | 8.40 |
| CHEMBL2170558 | — | — | 1 | 8.30 |
| CHEMBL2170724 | — | — | 1 | 8.00 |
| CHEMBL394528 | AGLAFOLIN | — | 1 | 8.00 |
| CHEMBL2170709 | — | — | 1 | 7.96 |
| CHEMBL2169895 | — | — | 1 | 7.54 |
| CHEMBL2170716 | — | — | 1 | 7.46 |
| CHEMBL2170719 | — | — | 1 | 7.46 |
| CHEMBL2170553 | — | — | 1 | 7.46 |
| CHEMBL2170708 | — | — | 1 | 7.40 |
| CHEMBL2170723 | — | — | 1 | 7.30 |
| CHEMBL2170704 | — | — | 1 | 7.10 |
| CHEMBL2170717 | — | — | 1 | 6.92 |
| CHEMBL2170720 | — | — | 1 | 6.77 |
| CHEMBL2170552 | — | — | 1 | - |
| CHEMBL2170712 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2170713 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL2170563 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2170562 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL555196 | SILVESTROL | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL2170556 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL2170714 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2170555 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2170703 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2170559 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2170722 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2170561 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2170560 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2170718 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2170725 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2170557 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2170558 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2170724 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL394528 | AGLAFOLIN | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2170709 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2169895 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2170719 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2170553 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2170716 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2170708 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2170723 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2170704 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2170717 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2170720 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2170554 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL2170711 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL2170707 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL2170705 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL2170710 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL2170706 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL2170721 | — | EC50 | > | 2000.0 | nM | - |
| CHEMBL2170715 | — | EC50 | > | 200.0 | nM | - |
| CHEMBL2170712 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL2170552 | — | Inhibition | - | % | - |