Assay Detail
Functional
CHEMBL2176060
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of ABCA1 mRNA expression in human MC65 cells after 24 hrs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MC65 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.90 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22373 | CL-976 | — | 1 | 6.22 |
| CHEMBL520938 | — | — | 1 | 6.05 |
| CHEMBL2170736 | — | — | 1 | 5.96 |
| CHEMBL2170728 | — | — | 1 | 5.89 |
| CHEMBL2170832 | — | — | 1 | 5.66 |
| CHEMBL2170821 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22373 | CL-976 | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL520938 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2170736 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2170728 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2170832 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2170821 | — | EC50 | = | 2500.0 | nM | 5.60 |