Assay Detail
Binding
CHEMBL2176106
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of amyloid beta (1 to 42) aggregation after 24 hrs by Thioflavin-T fluorescence assay
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and structure-activity relationship of N-arylnaphthylamine derivatives as amyloid aggregation inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 5.34 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL482392 | — | — | 1 | 7.00 |
| CHEMBL480438 | — | — | 1 | 6.00 |
| CHEMBL2171963 | — | — | 1 | 6.00 |
| CHEMBL2171877 | — | — | 1 | 5.96 |
| CHEMBL521083 | — | — | 1 | 5.70 |
| CHEMBL2171958 | — | — | 1 | 5.66 |
| CHEMBL2171864 | — | — | 1 | 5.62 |
| CHEMBL2171865 | — | — | 1 | 5.58 |
| CHEMBL2171957 | — | — | 1 | 5.57 |
| CHEMBL2171962 | — | — | 1 | 5.29 |
| CHEMBL2171959 | — | — | 1 | 5.27 |
| CHEMBL2171857 | — | — | 1 | 5.25 |
| CHEMBL2171872 | — | — | 1 | 5.24 |
| CHEMBL2171873 | — | — | 1 | 4.96 |
| CHEMBL2171861 | — | — | 1 | 4.85 |
| CHEMBL2171867 | — | — | 1 | 4.47 |
| CHEMBL177880 | PAMOIC ACID | — | 1 | 4.42 |
| CHEMBL2171964 | — | — | 1 | 4.34 |
| CHEMBL2171961 | — | — | 1 | 4.24 |
| CHEMBL2171953 | — | — | 1 | - |
| CHEMBL2171866 | — | — | 1 | - |
| CHEMBL2171954 | — | — | 1 | - |
| CHEMBL2171955 | — | — | 1 | - |
| CHEMBL2171956 | — | — | 1 | - |
| CHEMBL2171876 | — | — | 1 | - |
| CHEMBL2171875 | — | — | 1 | - |
| CHEMBL2171960 | — | — | 1 | - |
| CHEMBL2171874 | — | — | 1 | - |
| CHEMBL2171871 | — | — | 1 | - |
| CHEMBL2171965 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL482392 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL480438 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2171963 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2171877 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL521083 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2171958 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2171864 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2171865 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2171957 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2171962 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL2171959 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL2171857 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2171872 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL2171873 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL2171861 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL2171867 | — | IC50 | = | 33600.0 | nM | 4.47 |
| CHEMBL177880 | PAMOIC ACID | IC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL2171964 | — | IC50 | = | 46100.0 | nM | 4.34 |
| CHEMBL2171961 | — | IC50 | = | 57400.0 | nM | 4.24 |
| CHEMBL2171868 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2171863 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2171862 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2171869 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2171860 | — | IC50 | - | — | - | |
| CHEMBL2171859 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL2171858 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2171870 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2171856 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2171855 | — | IC50 | - | — | - | |
| CHEMBL2171966 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL2171965 | — | IC50 | - | — | - | |
| CHEMBL2171871 | — | IC50 | - | — | - | |
| CHEMBL2171874 | — | IC50 | - | — | - | |
| CHEMBL2171960 | — | IC50 | - | — | - | |
| CHEMBL2171875 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2171876 | — | IC50 | - | — | - | |
| CHEMBL2171956 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2171955 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2171954 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2171866 | — | IC50 | - | — | - | |
| CHEMBL2171953 | — | IC50 | > | 100000.0 | nM | - |