Assay Detail
Binding
CHEMBL2176209
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant SIRT1 expressed in Escherichia coli using Fluor de Lys substrate by fluorescence assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-1 (CHEMBL4506) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.08 | 5.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL596657 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL596657 | — | IC50 | = | 8400.0 | nM | 5.08 |