Assay Detail
Functional
CHEMBL2176296
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Cytoprotection in diethyl maleate-treated human Friedreich's ataxia lymphocytes incubated for 17 hrs before diethyl maleate challenge by trypan blue dye exclusion method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.34 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2172357 | — | — | 1 | 6.82 |
| CHEMBL2172356 | — | — | 1 | 6.42 |
| CHEMBL2172355 | — | — | 1 | 6.25 |
| CHEMBL252556 | IDEBENONE | 4.0 | 1 | 6.14 |
| CHEMBL2172360 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2172357 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2172356 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2172355 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL252556 | IDEBENONE | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL2172360 | — | EC50 | = | 840.0 | nM | 6.08 |