Assay Detail
Binding
CHEMBL2176358
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG expressed in CHOK1 cells by patch clamp technique
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Exploration of novel 3-substituted azetidine derivatives as triple reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.06 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2171418 | — | — | 1 | 6.75 |
| CHEMBL2171417 | — | — | 1 | 6.08 |
| CHEMBL2171416 | — | — | 1 | 6.01 |
| CHEMBL2171419 | — | — | 1 | 5.81 |
| CHEMBL2171415 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2171418 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2171417 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL2171416 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL2171419 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL2171415 | — | IC50 | = | 2200.0 | nM | 5.66 |