Assay Detail
Binding
CHEMBL2176367
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Inhibition of ALK Tyr1604 phosphorylation by cell based assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The discovery and optimization of a novel class of potent, selective, and orally bioavailable anaplastic lymphoma kinase (ALK) inhibitors with potential utility for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.81 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2172311 | — | — | 1 | 8.80 |
| CHEMBL2172312 | — | — | 1 | 8.70 |
| CHEMBL2172330 | — | — | 1 | 8.40 |
| CHEMBL2172332 | — | — | 1 | 8.40 |
| CHEMBL2172308 | — | — | 1 | 8.40 |
| CHEMBL2172306 | — | — | 1 | 8.40 |
| CHEMBL2172328 | — | — | 1 | 8.30 |
| CHEMBL2172333 | — | — | 1 | 8.30 |
| CHEMBL2172334 | — | — | 1 | 8.22 |
| CHEMBL2172325 | — | — | 1 | 8.15 |
| CHEMBL2172331 | — | — | 1 | 8.10 |
| CHEMBL2172310 | — | — | 1 | 8.10 |
| CHEMBL2172307 | — | — | 1 | 8.10 |
| CHEMBL2172335 | — | — | 1 | 8.10 |
| CHEMBL2172309 | — | — | 1 | 7.89 |
| CHEMBL2172324 | — | — | 1 | 7.75 |
| CHEMBL2172327 | — | — | 1 | 7.36 |
| CHEMBL2172322 | — | — | 1 | 7.32 |
| CHEMBL2172323 | — | — | 1 | 7.27 |
| CHEMBL2172337 | — | — | 1 | 6.96 |
| CHEMBL2172336 | — | — | 1 | 6.84 |
| CHEMBL2172329 | — | — | 1 | 6.83 |
| CHEMBL2172305 | — | — | 1 | 6.46 |
| CHEMBL2172326 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2172311 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2172312 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2172330 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2172332 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2172308 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2172306 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2172328 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2172333 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2172334 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2172325 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2172331 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2172310 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2172307 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2172335 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2172309 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2172324 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2172327 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2172322 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL2172323 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL2172337 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL2172336 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL2172329 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL2172305 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL2172326 | — | IC50 | = | 562.0 | nM | 6.25 |