Assay Detail
Binding
CHEMBL2176371
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Inhibition of ALK enzyme
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The discovery and optimization of a novel class of potent, selective, and orally bioavailable anaplastic lymphoma kinase (ALK) inhibitors with potential utility for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 8.65 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2172308 | — | — | 1 | 9.00 |
| CHEMBL2172311 | — | — | 1 | 9.00 |
| CHEMBL2172314 | — | — | 1 | 9.00 |
| CHEMBL2172315 | — | — | 1 | 9.00 |
| CHEMBL2172316 | — | — | 1 | 9.00 |
| CHEMBL2172317 | — | — | 1 | 9.00 |
| CHEMBL2172324 | — | — | 1 | 9.00 |
| CHEMBL2172321 | — | — | 1 | 9.00 |
| CHEMBL2172304 | — | — | 1 | 9.00 |
| CHEMBL2172335 | — | — | 1 | 8.92 |
| CHEMBL2172306 | — | — | 1 | 8.85 |
| CHEMBL2172312 | — | — | 1 | 8.82 |
| CHEMBL2172330 | — | — | 1 | 8.80 |
| CHEMBL2172333 | — | — | 1 | 8.80 |
| CHEMBL2172310 | — | — | 1 | 8.72 |
| CHEMBL2172319 | — | — | 1 | 8.70 |
| CHEMBL2172325 | — | — | 1 | 8.70 |
| CHEMBL2172313 | — | — | 1 | 8.70 |
| CHEMBL2172302 | — | — | 1 | 8.70 |
| CHEMBL2172307 | — | — | 1 | 8.70 |
| CHEMBL2172305 | — | — | 1 | 8.70 |
| CHEMBL2172328 | — | — | 1 | 8.70 |
| CHEMBL2172334 | — | — | 1 | 8.70 |
| CHEMBL2172332 | — | — | 1 | 8.70 |
| CHEMBL2172331 | — | — | 1 | 8.70 |
| CHEMBL2172309 | — | — | 1 | 8.59 |
| CHEMBL2172303 | — | — | 1 | 8.52 |
| CHEMBL2172323 | — | — | 1 | 8.52 |
| CHEMBL2172336 | — | — | 1 | 8.52 |
| CHEMBL2172320 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2172308 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2172311 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2172314 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2172315 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2172316 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2172317 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2172324 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2172321 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2172304 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2172335 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2172306 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2172312 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2172330 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2172333 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2172310 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL2172325 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2172313 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2172302 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2172334 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2172307 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2172328 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2172332 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2172331 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2172319 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2172305 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2172309 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL2172336 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2172301 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2172320 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2172323 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2172303 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2172322 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2172318 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2172329 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2172337 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL2172327 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2172326 | — | IC50 | = | 24.0 | nM | 7.62 |