Assay Detail
Binding
CHEMBL2176529
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PDE4D-mediated [3H]CAMP hydrolysis after 30 to 60 mins by scintillation proximity assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Solubility-driven optimization of phosphodiesterase-4 inhibitors leading to a clinical candidate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.51 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2172376 | — | — | 1 | 8.22 |
| CHEMBL2172370 | — | — | 1 | 7.72 |
| CHEMBL2172373 | — | — | 1 | 7.62 |
| CHEMBL2172367 | — | — | 1 | 7.52 |
| CHEMBL2172369 | — | — | 1 | 7.52 |
| CHEMBL2172374 | — | — | 1 | 7.50 |
| CHEMBL2172375 | — | — | 1 | 7.39 |
| CHEMBL2172366 | — | — | 1 | 7.35 |
| CHEMBL2172368 | — | — | 1 | 7.29 |
| CHEMBL2172371 | — | — | 1 | 7.29 |
| CHEMBL2172372 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2172376 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2172370 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2172373 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2172367 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2172369 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2172374 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2172375 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2172366 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2172368 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL2172371 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL2172372 | — | IC50 | = | 64.0 | nM | 7.19 |