Assay Detail
Binding
CHEMBL2176645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Modulation of gamma-secretase expressed in CHO cells co-expressing wild type APP and PS1 assessed as inhibition of amyloid beta-42 production sandwich ELISA
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.51 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2169959 | — | — | 1 | 7.52 |
| CHEMBL2169955 | — | — | 1 | 7.30 |
| CHEMBL2169963 | — | — | 1 | 7.17 |
| CHEMBL2169962 | — | — | 1 | 7.06 |
| CHEMBL2169954 | — | — | 1 | 6.72 |
| CHEMBL2169961 | — | — | 1 | 6.52 |
| CHEMBL2169948 | — | — | 1 | 6.46 |
| CHEMBL2169952 | — | — | 1 | 6.30 |
| CHEMBL2169957 | — | — | 1 | 6.21 |
| CHEMBL2169953 | — | — | 1 | 6.00 |
| CHEMBL2169958 | — | — | 1 | 6.00 |
| CHEMBL2169949 | — | — | 1 | 5.70 |
| CHEMBL2169950 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2169959 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2169955 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2169963 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL2169962 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL2169954 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2169961 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2169948 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2169952 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2169957 | — | IC50 | = | 616.0 | nM | 6.21 |
| CHEMBL2169953 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2169958 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2169949 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2169950 | — | IC50 | = | 2200.0 | nM | 5.66 |