Assay Detail
Binding
CHEMBL2182352
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]IMPY from amyloid beta (1 to 42) fibrils after 2 hrs by gamma-counting analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel ¹⁸F-labeled benzoxazole derivatives as potential positron emission tomography probes for imaging of cerebral β-amyloid plaques in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.52 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2158613 | — | — | 1 | 9.10 |
| CHEMBL1258462 | — | — | 1 | 9.00 |
| CHEMBL1774460 | — | — | 1 | 8.70 |
| CHEMBL1774458 | — | — | 1 | 8.62 |
| CHEMBL1774461 | FLORBETAPIR F 18 | 4.0 | 1 | 8.54 |
| CHEMBL2178553 | — | — | 1 | 8.41 |
| CHEMBL1774459 | — | — | 1 | 8.41 |
| CHEMBL2178556 | — | — | 1 | 8.41 |
| CHEMBL2178554 | — | — | 1 | 8.03 |
| CHEMBL2178555 | — | — | 1 | 8.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2158613 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL1258462 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1774460 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1774458 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL1774461 | FLORBETAPIR F 18 | Ki | = | 2.87 | nM | 8.54 |
| CHEMBL2178553 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL1774459 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL2178556 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL2178554 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL2178555 | — | Ki | = | 9.5 | nM | 8.02 |