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Assay Detail

CHEMBL2182385

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human KB cells incubated for 72 hrs by MTS assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KB
Confidence 1 — Organism
Curated By Autocuration

Target

KB (CHEMBL398)
Type CELL-LINE
Organism Homo sapiens

Publication

Flavaglines as potent anticancer and cytoprotective agents.
Ribeiro N, Thuaud F, Bernard Y, Gaiddon C, Cresteil T, Hild A, Hirsch EC, Michel PP, Nebigil CG, Désaubry L.
J Med Chem (2012) 55 : 10064 -10073
PubMed 23072299 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 8.30 9.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3545252 DOCETAXEL 4.0 1 9.77
CHEMBL159 VINBLASTINE 4.0 1 9.10
CHEMBL2179345 1 8.92
CHEMBL1651465 1 8.72
CHEMBL2179337 1 8.68
CHEMBL556074 1 8.62
CHEMBL2179344 1 8.62
CHEMBL2179343 1 8.55
CHEMBL2179335 1 8.54
CHEMBL2179713 1 8.46
CHEMBL2179334 1 8.44
CHEMBL2179717 1 8.24
CHEMBL2179339 1 8.18
CHEMBL2179715 1 8.11
CHEMBL2179714 1 8.08
CHEMBL2179336 1 8.00
CHEMBL2179342 1 8.00
CHEMBL2179340 1 8.00
CHEMBL2179716 1 7.43
CHEMBL53463 DOXORUBICIN 4.0 1 7.40
CHEMBL2179341 1 7.39
CHEMBL2179338 1 7.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3545252 DOCETAXEL IC50 = 0.17 nM 9.77
CHEMBL159 VINBLASTINE IC50 = 0.8 nM 9.10
CHEMBL2179345 IC50 = 1.2 nM 8.92
CHEMBL1651465 IC50 = 1.9 nM 8.72
CHEMBL2179337 IC50 = 2.1 nM 8.68
CHEMBL556074 IC50 = 2.4 nM 8.62
CHEMBL2179344 IC50 = 2.4 nM 8.62
CHEMBL2179343 IC50 = 2.8 nM 8.55
CHEMBL2179335 IC50 = 2.9 nM 8.54
CHEMBL2179713 IC50 = 3.5 nM 8.46
CHEMBL2179334 IC50 = 3.6 nM 8.44
CHEMBL2179717 IC50 = 5.8 nM 8.24
CHEMBL2179339 IC50 = 6.6 nM 8.18
CHEMBL2179715 IC50 = 7.8 nM 8.11
CHEMBL2179714 IC50 = 8.4 nM 8.08
CHEMBL2179336 IC50 = 10.0 nM 8.00
CHEMBL2179342 IC50 = 9.9 nM 8.00
CHEMBL2179340 IC50 = 10.0 nM 8.00
CHEMBL2179716 IC50 = 37.0 nM 7.43
CHEMBL53463 DOXORUBICIN IC50 = 40.0 nM 7.40
CHEMBL2179341 IC50 = 41.0 nM 7.39
CHEMBL2179338 IC50 = 50.0 nM 7.30