Assay Detail
Binding
CHEMBL2182409
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Inhibition of human 5HT3R
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of (2S,3R)-N-[2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selective α7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.02 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365323 | — | — | 1 | 7.30 |
| CHEMBL2179862 | — | — | 1 | 4.73 |
| CHEMBL1258006 | BRADANICLINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365323 | — | Ki | = | 49.8 | nM | 7.30 |
| CHEMBL2179862 | — | Ki | = | 18600.0 | nM | 4.73 |
| CHEMBL1258006 | BRADANICLINE | Ki | > | 10000.0 | nM | - |