Assay Detail
Functional
CHEMBL2182645
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Antiproliferative activity against human SJSA1 cells after 3 days by EdU incorporation assay in presence of 10% human serum
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SJSA-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based design of novel inhibitors of the MDM2-p53 interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.41 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2059435 | — | — | 1 | 7.17 |
| CHEMBL2177189 | — | — | 1 | 6.77 |
| CHEMBL2059300 | — | — | 1 | 6.72 |
| CHEMBL2177191 | — | — | 1 | 6.68 |
| CHEMBL2177188 | — | — | 1 | 6.51 |
| CHEMBL2177187 | — | — | 1 | 6.32 |
| CHEMBL2177190 | — | — | 1 | 6.27 |
| CHEMBL191334 | NUTLIN-3 | — | 1 | 6.16 |
| CHEMBL2177186 | — | — | 1 | 6.01 |
| CHEMBL2177813 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2059435 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL2177189 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2059300 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2177191 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2177188 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL2177187 | — | IC50 | = | 476.0 | nM | 6.32 |
| CHEMBL2177190 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2177186 | — | IC50 | = | 965.0 | nM | 6.01 |
| CHEMBL2177813 | — | IC50 | = | 3350.0 | nM | 5.47 |