Assay Detail
Functional
CHEMBL2182829
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human dopamine D2 receptor expressed in CHOp cells assessed as inhibition of quinpirol-induced mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHOp |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.84 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180641 | — | — | 1 | 5.90 |
| CHEMBL2180639 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180641 | — | IC50 | = | 1252.0 | nM | 5.90 |
| CHEMBL2180639 | — | IC50 | = | 1647.0 | nM | 5.78 |