Assay Detail
Binding
CHEMBL2182832
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]YM-09151-2 from human dopamine D2 receptor expressed in CHOp cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHOp |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.33 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1188090 | — | — | 1 | 7.19 |
| CHEMBL2180638 | — | — | 1 | 6.93 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 6.38 |
| CHEMBL2180639 | — | — | 1 | 6.35 |
| CHEMBL2180641 | — | — | 1 | 6.08 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 5.93 |
| CHEMBL2180640 | — | — | 1 | 5.91 |
| CHEMBL2180637 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1188090 | — | Ki | = | 64.4 | nM | 7.19 |
| CHEMBL2180638 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL59 | DOPAMINE | Ki | = | 422.0 | nM | 6.38 |
| CHEMBL2180639 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL2180641 | — | Ki | = | 831.0 | nM | 6.08 |
| CHEMBL240773 | QUINPIROLE | Ki | = | 1185.0 | nM | 5.93 |
| CHEMBL2180640 | — | Ki | = | 1233.0 | nM | 5.91 |
| CHEMBL2180637 | — | Ki | = | 1420.0 | nM | 5.85 |