Assay Detail
Binding
CHEMBL2183586
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DGAT1 in mouse liver microsomes
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Diacylglycerol O-acyltransferase 1 (CHEMBL1075284) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.00 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297354 | AZD-7687 | 1.0 | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297354 | AZD-7687 | IC50 | = | 100.0 | nM | 7.00 |