Assay Detail
Binding
CHEMBL2183587
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DGAT1 in rat adipose tissue assessed as reduction in triacylglycerol synthesis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Adipose tissue |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Diacylglycerol O-acyltransferase 1 (CHEMBL6129) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.05 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297354 | AZD-7687 | 1.0 | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297354 | AZD-7687 | IC50 | = | 90.0 | nM | 7.05 |