Assay Detail
Binding
CHEMBL2183648
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Inhibition of GSK3beta
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel 3-Azaindolyl-4-arylmaleimides exhibiting potent antiangiogenic efficacy, protein kinase inhibition, and antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.32 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180882 | — | — | 1 | 8.05 |
| CHEMBL2177142 | — | — | 1 | 7.40 |
| CHEMBL201511 | MALEIMIDE | — | 1 | 7.15 |
| CHEMBL2180881 | — | — | 1 | 6.67 |
| CHEMBL2180878 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180882 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2177142 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL201511 | MALEIMIDE | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL2180881 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL2180878 | — | IC50 | >= | 10000.0 | nM | - |