Assay Detail
Binding
CHEMBL2183649
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGFR2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel 3-Azaindolyl-4-arylmaleimides exhibiting potent antiangiogenic efficacy, protein kinase inhibition, and antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.91 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180878 | — | — | 1 | 7.43 |
| CHEMBL2180882 | — | — | 1 | 7.32 |
| CHEMBL201511 | MALEIMIDE | — | 1 | 7.16 |
| CHEMBL2180881 | — | — | 1 | 6.43 |
| CHEMBL2177142 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180878 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2180882 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL201511 | MALEIMIDE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2180881 | — | IC50 | = | 373.0 | nM | 6.43 |
| CHEMBL2177142 | — | IC50 | = | 590.0 | nM | 6.23 |