Assay Detail
Functional
CHEMBL2184101
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Agonist activity at human TLR2 expressed in HEK293 cells assessed as induction of NF-kappaB signaling after 24 hrs by luminescence based luciferase reporter gene assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel toll-like receptor 2 ligands for targeted pancreatic cancer imaging and immunotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.58 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2179400 | — | — | 1 | 8.43 |
| CHEMBL2179403 | — | — | 1 | 7.70 |
| CHEMBL2179399 | — | — | 1 | 7.64 |
| CHEMBL2179778 | — | — | 1 | 7.60 |
| CHEMBL3350702 | — | — | 1 | 7.47 |
| CHEMBL2179402 | — | — | 1 | 7.41 |
| CHEMBL2179779 | — | — | 1 | 7.25 |
| CHEMBL2179404 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2179400 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL2179403 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2179399 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2179778 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3350702 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2179402 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2179779 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL2179404 | — | EC50 | = | 78.0 | nM | 7.11 |