Assay Detail
Binding
CHEMBL2184332
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Aurora kinase A/TPX2 complex using gamma-[32P]ATP incubated for 1 hr by autoradiography
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Crystal structure of human aurora B in complex with INCENP and VX-680.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.41 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514409 | HESPERADIN | — | 1 | 7.96 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 7.82 |
| CHEMBL202721 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514409 | HESPERADIN | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL202721 | — | IC50 | = | 360.0 | nM | 6.44 |