Assay Detail
Binding
CHEMBL2184356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and pharmacological profile of new 1H-indazole-3-carboxamide and 2H-pyrrolo[3,4-c]quinoline derivatives as selective serotonin 4 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.26 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2179672 | — | — | 1 | 8.00 |
| CHEMBL2179670 | — | — | 1 | 7.70 |
| CHEMBL2179671 | — | — | 1 | 7.70 |
| CHEMBL2179675 | — | — | 1 | 7.30 |
| CHEMBL2179676 | — | — | 1 | 5.91 |
| CHEMBL2179702 | — | — | 1 | 5.58 |
| CHEMBL2179674 | — | — | 1 | 5.00 |
| CHEMBL3216126 | — | — | 1 | 4.65 |
| CHEMBL3215681 | — | — | 1 | 4.49 |
| CHEMBL2179707 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2179672 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2179670 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2179671 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2179675 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2179676 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL2179702 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL2179674 | — | IC50 | = | 9960.0 | nM | 5.00 |
| CHEMBL3216126 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL3215681 | — | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL2179707 | — | IC50 | > | 100000.0 | nM | - |